[GANN, 58, 291-295; June, 1967] UDC 618.19-006-092:621.664:612.018.2[577.176.31] INFLUENCE OF TESTOSTERONE IN INTACT AND MAMMECTOMISED FEMALE MICE*1

نویسندگان

  • Plate LI
  • Jer K. MODY
چکیده

Spontaneous mammary tumour incidence, at death, of intact C3H(Jax) virgin female mice was not altered by treatment with testosterone propionate, given upto the beginning of tumour age. In 6 out of 12 mice, testosterone delayed the appearance of tumours and thus added to their longevity significantly. The type of mammary tumours obtained in testosterone-treated female mice was largely similar to the spontaneous and unlike the chemically induced ones. The yield of ovarian tumours induced by 7,12-dimethylbenz[a]anthracene (DMBA) was significantly greater in C3H(Jax) mammectomised mice when treated with testosterone. It is suggested that testosterone has a promoting action for chemically induced ovarian tumours in mice. Subcutaneous fibrosarcomas were induced in DMBA-treated mammectomised C3H(Jax) female mice given testosterone. They were not obtained in comparable groups treated with testosterone alone or with DMBA alone. This observation supports the suggestion that testosterone has a promoting role in the mechanism of chemical carcinogenesis.

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تاریخ انتشار 2008